Ph.D. Department of Mechanical & Industrial Engineering, Institute of
Biomaterials and Biomedical Engineering, University of Toronto
Adjunct Researcher at General Hospital of Guangzhou Military Command of PLA
B.A.Sc. Department of Mechanical & Industrial Engineering, University of Toronto
Dongfang’s research is primarily focusing on developing microfluidic system to segregate, capture and recover Circulating Tumor Cells (CTCs) in human body fluid. He joined the Cellular Biomechanics Laboratory (CBL) at University of Toronto in September 2016. He is now collaborating with General Hospital of Guangzhou Military Command of PLA on the project of designing and experimenting a microfluidic platform to rapidly and accurately detect Myeloma Cells in human peripheral blood and in bone marrow. Multiple myeloma (MM) is the second most common haematological malignancy and represents approximately 20% of deaths from haematological malignancies. In MM, circulating myeloma cancer cells (CMCs) are considered an unfavourable prognostic factor and indicate an aggressive form of the disease, and therefore detecting myeloma cancer cells in peripheral blood can be used as a powerful prognostic tool in this disorder. Currently, the main diagnose approach, flow cytometry cannot fulfill the demand due to its low sensitivity. In this research project, a microfluidic platform is developed to detect the myeloma cancer cells in peripheral blood, which can reach an order of 10’s higher sensitivity than flow cytometry. In addition, the microfluidic platform will be designed in a way which can recover the myeloma cancer cells out from the other background cells, which will be carried on for further clinical study, such as single cell gene sequencing, testing the effect of new drugs as well as evaluating the response of cancer therapy.