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Ph.D., Institute of Biomaterials Biomedical Engineering, University of Toronto
Supervisor: Lidan You
B.Sc.E., Mechanical Engineering – Materials Science Option, Queen’s University
Bone remodeling occurs through the coordination of the basic multicellular unit (BMU). It has been shown that the BMU tends to travel in the direction of mechanical loading in bone and, as such, the mechanosensing osteocyte has been chosen as the prime candidate for guiding the BMU during remodeling. My work focuses on the communication of the osteocytes to the bone cells in the BMU under a variety of physiological conditions. To study this intercellular communication I have developed a microfluidic co-culture device to perform my experiments.