Publications

Liangcheng Henry Xu, Han Shao, Ma YHVLidan You. “Osteocytes as an in Vitro Cell Model for Bone Remodeling Under Mechanical Loading” Journal of Orthopaedic Research (2019) PDF

Xueting Mei, Middleton K, Shim D, Wan Q, Liangcheng Xu, Ma YHV, Devadas D, Walji N, Wang L, Young E, Lidan You. “Microfluidic platform for studying osteocyte mechanoregulation of breast cancer bone metastasis” Integrative Biology, (2019) PDF

Ma YHV, Xu H, Mei X, Middleton K, You L. “Mechanically stimulated osteocytes reduce the bone‐metastatic potential of breast cancer cells in vitro by signaling through endothelial cells.” Journal of cellular biochemistry. 2018 Nov. PDF

Ma YHV, Middleton K, You L, Sun Y. “A review of microfluidic approaches for investigating cancer extravasation during metastasis.” Microsystems & Nanoengineering. 2018 Apr 9;4:17104. PDF

Middleton K, Kondiboyina A, Borrett M, Cui Y, Mei X, You L. “Microfluidics approach to investigate the role of dynamic similitude in osteocyte mechanobiology.” Journal of Orthopaedic Research. 2018 Feb;36(2):663-671. PDF

Ma YHV, Lam C, Dalmia S, Gao P, Young J, Middleton K, Liu C, Xu H, You L. “Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling.” Journal of cellular biochemistry. 2018 Jan. PDF

Middleton K, Al-Dujaili S, Mei X, Günther A, You L. “Microfluidic co-culture platform for investigating osteocyte-osteoclast signalling during fluid shear stress mechanostimulation.” J Biomech. 2017 Jul 5;59:35-42. PDF

Liu C, Zhang X, Wu M, You L. “Mechanical loading up-regulates early remodeling signals from osteocytes subjected to physical damage.” J Biomech. 2015 Dec 16;48(16):4221-8. PDF

Nirmalanandhan VS, Hurren R, Cameron WD, Gronda M, Shamas-Din A, You L, Minden MD, Rocheleau JV, Schimmer AD. “Increased pressure alters plasma membrane dynamics and renders acute myeloid leukemia cells resistant to daunorubicin.” Haematologica. 2015 Oct;100(10):e406-8. PDF

Parajuli A, Liu C, Li W, Gu X, Lai X, Pei S, Price C, You L, Lu XL, Wang L. “Bone’s responses to mechanical loading are impaired in type 1 diabetes.” Bone. 2015 Dec;81:152-60. PDF

Zhang JN, Zhao Y, Liu C, Han ES, Yu X, Lidington D, Bolz SS, You L.”The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction” Bone. 2015 Oct;79:71-8. PDF

Wei C, Fan B, Chen D, Liu C, Wei Y, Huo B, You L, Wang J, Chen “Osteocyte culture in microfluidic devices” J.Biomicrofluidics. 2015 Jan 26;9(1):014109 PDF

Han, E. S., Yu, X., Zhao, Y., Bolz, S., Lidington, D., Heximer, S., Simmons, C. A., You, L. “The Role of the Sphingosine-1-Phosphate Signaling Pathway in Osteocyte Mechanotransduction” (2015) Orthopaedic Research Society 55th Annual Meeting PDF

Zhang YL, Li J, To S, Zhang Y, Ye X, You L, Sun Y “Automated nanomanipulation for nanodevice construction” Nanotechnology. 2012 Feb 17;23(6):065304 PDF

Jason Li, Emily Rose, Daniel Frances, Yu Sun, Lidan You “Effect of oscillating fluid flow stimulation on osteocyte mRNA expression” Journal of Biomechanics (2012) PDF

Saja Al-Dujaili, Chao Liu, Axel Guenther, Lidan You (2012) “Osteocytes exhibit multiple calcium oscillations in response to mechanical loading” ORS 58th Annual Meeting, February 4-7, 2012, San Francisco, California, USA. PDF

Jia Ning Zhang, Chao Liu, Lidan You (2012) “The Effect of Mechanical Stimulation on Osteocyte Chemo-Sensitivity” ORS 58th Annual Meeting, February 4-7, 2012, San Francisco, California, USA. PDF

Wing-Yee Cheung, Craig A. Simmons, Lidan You, “Osteocyte apoptosis regulates osteoclast precursor adhesion via osteocytic IL-6 secretion and endothelial ICAM-1 expression” Bone 50 (2012) 104–110 PDF

Saja A. Al-Dujaili, Esther Lau, Hashem Al-Dujaili, Kyle Tsang, Axel Guenther, Lidan You, “Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro”, Journal of Cellular Biochemistry 112:2412-2423 (2011) PDF

Weinbaum S, Duan Y, Thi MM, You L. “An Integrative Review of Mechanotransduction in Endothelial, Epithelial (Renal) and Dendritic Cells (Osteocytes).” Cell Mol Bioeng. 2011 Dec;4(4):510-537. PDF

Esther Lau, Whitaik David Lee, Jason Li, John E. Davies, Qianhong Wu, Liyun Wang, Lidan You, “Effect of low-magnitude, high-frequency vibration on osteogenic differentiation of rat mesenchymal stromal cells”, Journal of Orthopedic Research, 2011 Feb 22 PDF

Saja Al-Dujaili, Kyle Tsang, Lidan You (2011) “Apoptotic Osteocytes Directly and Indirectly Promote Osteoclast Formation” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.Emily Rose, Lidan You (2010) “Osteocytes differentially respond to different levels of shear stress” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. PDF

Wing-Yee Cheung, Chao Liu, Rachel Tonelli Zasarsky, Craig A. Simmons, Lidan You, “Osteocyte Apoptosis is Mechanically Regulated and Induces Angiogenesis In Vitro”, Journal of Orthopedic Research, 2011 April ;29(4):523-30 PDF

Esther Lau, Saja Al-Dujaili, Axel Guenther, Dawei Liu, Liyun Wang, Lidan You “Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts” Bone. Volume 46, Issue 6, June 2010, Pages 1508-1515 (Top 8 in downloads from Bone from April to June, 2010) PDF

Chao Liu, Yan Zhao, Wing-Yee Cheung, Ronak Gandhi, Liyun Wang, Lidan You “Effects of cyclic hydraulic pressure on osteocytes” Bone. Volume 46, Issue 5, May 2010, Pages 1449-1456 PDF

Jan-Hung Chen, Chao Liu, Lidan You, Craig A. Simmons “Boning up on Wolff’s Law: Mechanical regulation of the cells that make and maintain bone” Journal of Biomechanics 43 (2010) 108-118 (Top 10 in downloads from J. of Biomech from Jan. to Mar. 2010) PDF

Esther Lau, Hong Lu, Dawei Liu, Lidan You (2010) “Low-magnitude, high-frequency vibration inhibits osteoclast formation via soluble factors from MLO-Y4 osteocytes” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana.(oral) PDF

Chao Liu, Ronak Gandhi, Liyun Wang, Lidan You (2010) “Effect of Cyclic Hydraulic Pressure on Osteocytes” ORS 56th Annual Meeting, March 6-9, 2010 in New Orleans, Louisiana. PDF

Zhe Lu, Christopher Moraes, Yan Zhao, Lidan You, Craig A. Simmons, and Yu Sun (2010) “A Micromanipulation System for Single Cell Deposition” IEEE Conf. Robotics and Automation, Anchorage, Alaska, USA. May 3 – 8, 2010. (847 selected from 2062 submissions) PDF

Lau, E., Pang, Q., You, L. “Cellular and molecular mechanism underlying the anti-resorptive effect of low-magnitude, high-frequency vibrations on bone” (2009) Orthopaedic Research Society 55th Annual Meeting PDF

Lidan You, Sara Temiyasathit, Sean R. Coyer, Andreas J. Garcia, Christopher R. Jacobs “Bone Cells Grown on Micropatterned Surfaces are More Sensitive to Fluid Shear Stress”, Cellular and Molecular Bioengineering. 1(2-3): 182-188, 2008. PDF

Lidan You, Sara Temiyasathit, Eric Tao, Fritz Prinz, and Christopher R. Jacobs “3D Microfluidic Approach to Mechanical Stimulation of Osteocyte Processes”, Cellular and Molecular Bioengineering, 1(1): 103-107, 2008. PDF

You, L., Temiyasathit, S., Lee, P., Kim, C.H., Tummala, P., Yao, W., Kingery, W., (…), Jacobs, C.R. “Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading” (2008) Bone, 42 (1), pp. 172-179. PDF

Malone, A.M.D., Batra, N.N., Shivaram, G., Kwon, R.Y., You, L., Kim, C.H., Rodriguez, J., (…), Jacobs, C.R. “The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts” (2007) American Journal of Physiology – Cell Physiology, 292 (5), pp. C1830-C1836. PDF

Kim, C.H., You, L., Yellowley, C.E., Jacobs, C.R. “Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling” (2006) Bone, 39 (5), pp. 1043-1047. PDF

Nikhil N. Batra, Ying J. Li, Clare E. Yellowley, Lidan You, Amada Malone, Chi Hyun Kim, Christopher R. Jacobs (2005) “Effects of short term recovery periods on fluid induced signaling in osteoblastic cells” Journal of Biomechanics. 38: 1909-1917. PDF

Ying J. Li, Nikhil N. Batra, Lidan You, Stephen C. Meier, Ian A. Coe, Clare E. Yellowley, Christopher R. Jacobs (2004) “Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation” Journal of Orthopaedic Research 22: 1283-1289. PDF

Lidan You, Sheldon Weinbaum, Stephen C. Cowin, Mitchell B. Schaffler (2004) “Ultrastructure of the osteocytes process and its Pericellular Matrix” Anatomical Record 278A(2): 505-513. PDF

You, L., Cowin, S.C., Schaffler, M.B., Weinbaum, S. “A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix” (2001) Journal of Biomechanics, 34 (11), pp. 1375-1386. PDF

Weinbaum, S., Guo, P., You, L. “A new view of mechanotransduction and strain amplification in cells with microvilli and cell processes” (2001) Biorheology, 38 (2-3), pp. 119-142. PDF